Toll-like receptor agonist lipopeptides self-assemble into distinct nanostructures

被引：47
|
作者：
Hamley, Ian W. [1 ]
Kirkham, Steven [1 ]
Dehsorkhi, Ashkan [1 ]
Castelletto, Valeria [2 ]
Reza, Mehedi [3 ]
Ruokolainen, Janne [3 ]
机构：
[1] Univ Reading, Dept Chem, Whiteknights Reading RG6 6AD, Berks, England
[2] Natl Phys Lab, Teddington TW11 0LW, Middx, England
[3] Aalto Univ, Sch Sci, Dept Appl Phys, FI-00076 Aalto, Finland
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 100期
基金：
英国工程与自然科学研究理事会;
关键词：
PEPTIDE AMPHIPHILE; IMMUNE-RESPONSE; LIPOPROTEINS; MIXTURES; MICELLES; PYRENE;
D O I：
10.1039/c4cc07511k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The self-assembled structure of toll-like receptor agonist lipopeptides containing the CSK4 peptide sequence is examined in aqueous solution. A remarkable dependence of morphology on the number of attached hexadecyl lipid chains is demonstrated, with spherical micelle structures for mono- and di-lipidated structures observed, but flexible wormlike micelles for the homologue containing three lipid chains. The distinct modes of assembly may have an important influence on the bioactivity of this class of lipopeptide.
引用
收藏
页码：15948 / 15951
页数：4
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