Synthesis and characterizations of a highly sensitive and selective fluorescent probe for hydrogen sulfide

被引：37
|
作者：
Huang, Yan [1 ]
Zhang, Changyu [1 ]
Xi, Zhen [2 ,3 ]
Yi, Long [1 ]
机构：
[1] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
[2] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Natl Pesticide Engn Res Ctr Tianjin, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
[3] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Natl Pesticide Engn Res Ctr Tianjin, Dept Biol Chem, Tianjin 300071, Peoples R China
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 10期
关键词：
Bioimaging; Fluorescence probe; Hydrogen sulfide; NBD amine; Thiolysis; LIVING CELLS; H2S; REVEALS; GAS;
D O I：
10.1016/j.tetlet.2016.02.017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hydrogen sulfide (H2S) is an important endogenous signaling molecule with a variety of biological functions. To detect H2S in living biological systems, herein we developed a new fluorescent probe for highly sensitive and selective sensing of H2S in cells. The probe is based on coumarin-triazole as the fluorophore and thiolysis of the NBD (7-nitro-1,2,3-benzoxadiazole) amine as the receptor. Bioimaging experiments indicated that this probe could be used to monitor H2O2-induced H2S biosynthesis in yeast cells. Our results show that such thiolysis of the NBD amine can be used for the development of fluorescent H2S probes. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1187 / 1191
页数：5
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