Neutrophils in rheumatoid arthritis: More than simple final effectors

被引：166

作者：

Cascao, R. ^{[1
]}

Rosario, H. S. ^{[2
]}

Souto-Carneiro, M. M. ^{[3
]}

Fonseca, J. E. ^{[1
,4
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Mol Med, Rheumatol Res Unit, P-1649028 Lisbon, Portugal

[2] Univ Lisbon, Fac Med, Inst Mol Med, Microvasc Biol & Inflammat Unit, P-1649028 Lisbon, Portugal

[3] Univ Coimbra, Ctr Neurosci & Cell Biol, Autoimmun Grp, Coimbra, Portugal

[4] Hosp Santa Maria, Dept Rheumatol, Lisbon, Portugal

来源：

AUTOIMMUNITY REVIEWS | 2010年 / 9卷 / 08期

关键词：

Rheumatoid arthritis; Etiopathology; Neutrophils; Immune mediators; ROS; Apoptosis; SYNOVIAL-FLUID NEUTROPHILS; B-LYMPHOCYTE STIMULATOR; INFLAMMATORY DISEASE; POLYMORPHONUCLEAR NEUTROPHILS; ACTIVATED NEUTROPHILS; GROWTH-FACTOR; HUMAN BLOOD; IN-VITRO; T-CELLS; KAPPA-B;

D O I：

10.1016/j.autrev.2009.12.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rheumatoid arthritis is the most common inflammatory joint disease. The etiopathogenesis of this condition has been classically explained by a T cell-driven process. However, recent studies have highlighted the possible contribution of neutrophils for the early phases of RA physiopathology. These cells are phagocytic leukocytes that play crucial roles in the acute defense against pathogens while modulating the function of other immune cells and contributing to the perpetuation of an initial inflammatory response. The herein article reviews recent progresses in the understanding of the immunopathology of RA with a special emphasis on the role of neutrophils. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：531 / 535

页数：5

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