Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis

被引:20
|
作者
Batara, Don Carlo Ramos [1 ]
Choi, Moon-Chang [2 ]
Shin, Hyeon-Uk [1 ]
Kim, Hyunggee [3 ]
Kim, Sung-Hak [1 ]
机构
[1] Chonnam Natl Univ, Coll Agr & Life Sci, Dept Anim Sci, Gwangju 61186, South Korea
[2] Chosun Univ, Dept Biomed Sci, Gwangju 61452, South Korea
[3] Korea Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 02841, South Korea
基金
新加坡国家研究基金会;
关键词
glioblastoma multiforme; autophagy; treatment; NEWLY-DIAGNOSED GLIOBLASTOMA; HYPOXIA-INDUCED AUTOPHAGY; PHASE-II TRIAL; POTENTIATES TEMOZOLOMIDE CYTOTOXICITY; SUBEROYLANILIDE HYDROXAMIC ACID; PROMOTES CELL-PROLIFERATION; GLIOMA-CELLS; SIGNALING PATHWAY; IN-VITRO; VASCULOGENIC MIMICRY;
D O I
10.3390/cells10061411
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor in adults, with a poor median survival of approximately 15 months after diagnosis. Despite several decades of intensive research on its cancer biology, treatment for GBM remains a challenge. Autophagy, a fundamental homeostatic mechanism, is responsible for degrading and recycling damaged or defective cellular components. It plays a paradoxical role in GBM by either promoting or suppressing tumor growth depending on the cellular context. A thorough understanding of autophagy's pleiotropic roles is needed to develop potential therapeutic strategies for GBM. In this paper, we discussed molecular mechanisms and biphasic functions of autophagy in gliomagenesis. We also provided a summary of treatments for GBM, emphasizing the importance of autophagy as a promising molecular target for treating GBM.
引用
收藏
页数:28
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