The application of sulfur-containing peptides in drug discovery

被引：76
|
作者：
Zhao, Jiaoyan [1 ]
Jiang, Xuefeng [1 ,2 ]
机构：
[1] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China
[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Peptides; Disulfide; Thioether; Thiazole; Drug discovery; RECEPTOR AGONIST LIXISENATIDE; CALCIUM-SENSING RECEPTOR; PLACEBO-CONTROLLED TRIAL; HEART-FAILURE; DOUBLE-BLIND; SECONDARY HYPERPARATHYROIDISM; THERAPEUTIC PEPTIDES; NATRIURETIC PEPTIDE; PARATHYROID-HORMONE; BASAL INSULIN;
D O I：
10.1016/j.cclet.2018.05.026
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
recent decades, peptides as potential drugs were more and more explored with the development of non-oral medicine. There into, sulfur-containing peptide is one of the most popular aspects in peptide drugs due to the introduction of sulfur atoms leading unique properties. The purpose of the present review is to focus on the discovery of various sulfur-containing peptides with particular emphasis on their pharmacological mechanisms. This review is organized according to the structures of the sulfur containing peptides. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1079 / 1087
页数：9
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