New antiproliferative epoxysecosterols from Pseudopterogorgia americana

被引：28
|
作者：
Naz, S
Kerr, RG
Narayanan, R
机构：
[1] Florida Atlantic Univ, Ctr Mol Biol & Biotechnol, Dept Chem & Biochem, Boca Raton, FL 33431 USA
[2] Florida Atlantic Univ, Ctr Mol Biol & Biotechnol, Dept Biol Sci, Boca Raton, FL 33431 USA
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 32期
关键词：
NMR; mass spectrometery; steroids; anti-tumor compounds and anti-inflammatory compounds;
D O I：
10.1016/S0040-4039(00)01015-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new 9(11)-secogorgosterols containing oxirane rings at the C-5/C-6 position (1 and 2) were isolated from Pseudopterogorgia americana along with a known secogorgosterol (3). The structures were elucidated using detailed spectroscopic studies and the epoxysecosteroids were found to exhibit activity against prostate (LnCaD) and lung cancer (Calu-3) cell lines. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6035 / 6040
页数：6
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