Synthesis and cross-coupling reactions of solid-supported alkylzinc reagents

被引：9

作者：

Jackson, RFW

Oates, LJ

Block, MH

机构：

[1] Univ Newcastle Upon Tyne, Dept Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Astra Zeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 15期

关键词：

D O I：

10.1039/b003879m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydroboration of Wang-supported pent-4-enoic acid 1, followed by transmetallation with Et2Zn, gives a solid-supported zinc reagent, 2, which undergoes palladium-catalysed coupling with aryl iodides, to give the corresponding 5-arylpentanoic acids 3 in moderate to good yields, after cleavage from the resin using TFA.

引用

页码：1401 / 1402

页数：2

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