Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway

被引：5

作者：

Zhang, Meng-Ling ^{[1
,2
,3
,4
,5
]}

Yang, Qian ^{[1
]}

Zhu, Yan-Di ^{[1
]}

Zhang, Ya-Di ^{[1
]}

Zhang, Rui ^{[6
]}

Liu, Jian ^{[2
,3
,4
,5
]}

Zhao, Xiao-Yan ^{[1
]}

Dang, Qin-Yu ^{[1
]}

Huang, Dong-Xu ^{[1
]}

Zhang, Ming-Yuan ^{[1
]}

Wei, Yu-Chen ^{[1
]}

Hu, Zhuo ^{[1
]}

Cai, Xia-Xia ^{[1
]}

Gao, Li-Fang ^{[1
]}

Shan, Yang ^{[2
,3
,4
,5
]}

Yu, Huan-Ling ^{[1
]}

机构：

[1] Capital Med Univ, Sch Publ Hlth, Beijing Key Lab Environm Toxicol, Beijing 100069, Peoples R China

[2] Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Hunan Prov Key Lab Fruits & Vegetables Storage Pr, Changsha 410082, Hunan, Peoples R China

[3] Hunan Prov Key Lab Fruits & Vegetables Storage Pr, Changsha 410082, Hunan, Peoples R China

[4] Hunan Prov Int Joint Lab Fruits & Vegetables Proc, Qual & Safety, Changsha 410082, Hunan, Peoples R China

[5] Hunan Univ, Longping Branch Grad Sch, Changsha 410082, Hunan, Peoples R China

[6] Peking Univ, Sch Med Humanity, Beijing 100191, Peoples R China

来源：

NUTRIENTS | 2022年 / 14卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Nobiletin; placenta; hypoxia; RUPP; P53 signaling pathway; PREECLAMPSIA; MODEL; INJURY;

D O I：

10.3390/nu14112332

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

In this study, we aimed to evaluate the effect of Nobiletin (NOB) on the placenta of Sprague-Dawley (SD) rats that had undergone reduced uterine perfusion pressure (RUPP) surgery and to evaluate the safety of NOB intervention during pregnancy. The results showed that NOB alleviated placental hypoxia, attenuated placental cell apoptosis, and inhibited placental damage in RUPP rats. No side effect of NOB intervention during pregnancy was observed. BeWo cell lines with P53 knockdown were then constructed using lentiviral transfection, and the P53 signaling pathway was found to be essential for NOB to reduce hypoxia-induced apoptosis of the BeWo cell lines. In summary, NOB attenuated hypoxia-induced placental damage by regulating the P53 signaling pathway, and those findings may contribute some insights into the role of NOB in placental development and the prevention of placental-related diseases.

引用

页数：16

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