Identification of a novel tri-genotypic recombinant Hepatitis B virus in Bangladesh

被引：6

作者：

Shaha, Modhusudon ^{[1
]}

Rahman, Md. Hadisur ^{[2
]}

Jahan, Munira ^{[3
]}

Dey, Shuvra Kanti ^{[4
]}

Das, Keshob Chandra ^{[2
]}

Hashem, Abu ^{[1
]}

Salimullah, Md. ^{[2
]}

机构：

[1] Natl Inst Biotechnol, Microbial Biotechnol Div, Dhaka 1349, Bangladesh

[2] Natl Inst Biotechnol, Mol Biotechnol Div, Dhaka 1349, Bangladesh

[3] Bangabandhu Sheikh Mujib Med Univ, Dept Virol, Dhaka 1000, Bangladesh

[4] Jahangirnagar Univ, Dept Microbiol, Dhaka 1342, Bangladesh

来源：

VIRUS RESEARCH | 2018年 / 255卷

关键词：

Inter-genotypic recombinant; Hepatitis B virus; Liver fibrosis; Frameshift deletion; Bangladesh;

D O I：

10.1016/j.virusres.2018.07.014

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report a novel tri-genotypic recombinant Hepatitis B virus (HBV) strain circulating in Bangladesh. The strain is recombinant with the genotypes D, C and E, of which, genotype E was not reported before in Bangladesh. Additionally, the complete genome has a frameshift deletion of nine nucleotides from overlapping Surface and Polymerase genes, and a vaccine escape mutation, A128 V, in the surface protein. This is the first report with such unusual recombination event responsible for rapid liver cirrhosis in a 13 year old patient in Bangladesh. This report may alert the clinicians to take the measure to prevent an upcoming outbreak of recombinant HBV.

引用

页码：154 / 156

页数：3

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