Recent advances in lipidomics for disease research

被引：71

作者：

Yang, Li ^{[1
]}

Li, Min ^{[1
]}

Shan, Yabing ^{[1
,2
]}

Shen, Sensen ^{[1
]}

Bai, Yu ^{[1
]}

Liu, Huwei ^{[1
]}

机构：

[1] Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

[2] Natl Res Ctr Geoanal, Beijing, Peoples R China

来源：

JOURNAL OF SEPARATION SCIENCE | 2016年 / 39卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Biomarkers; Clinical diagnosis; Lipidomics; Metabolism; 2-DIMENSIONAL GAS-CHROMATOGRAPHY; IMAGING MASS-SPECTROMETRY; FATTY-ACID SYNTHASE; BREAST-CANCER; ALZHEIMERS-DISEASE; SHOTGUN LIPIDOMICS; HUMAN PLASMA; MITOCHONDRIAL DYSFUNCTION; ATHEROSCLEROTIC PLAQUES; URINARY PHOSPHOLIPIDS;

D O I：

10.1002/jssc.201500899

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Lipidomics is an important branch of metabolomics, which aims at the detailed analysis of lipid species and their multiple roles in the living system. In recent years, the development of various analytical methods for effective identification and characterization of lipids has greatly promoted the process of lipidomics. Meanwhile, as many diseases demonstrate a remarkable alteration in lipid profiles compared with that of healthy people, lipidomics has been extensively introduced to disease research. The comprehensive lipid profiling provides a chance to discover novel biomarkers for specific disease. In addition, it plays a crucial role in the study of lipid metabolism, which could illuminate the pathogenesis of diseases. In this review, after brief discussion of analytical methods for lipidomics in clinical research, we focus on the recent advances of lipidomics related to four types of diseases, including cancer, atherosclerosis, diabetes mellitus, and Alzheimer's disease.

引用

页码：38 / 50

页数：13

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