Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience

被引:2
|
作者
Nyk, Lukasz [1 ]
Kamecki, Hubert [1 ]
Krajewski, Wojciech [2 ]
Malkiewicz, Bartosz [2 ]
Szydelko, Tomasz [2 ]
Kubis, Markiian [2 ]
Slojewski, Marcin [3 ]
Kryst, Piotr [1 ]
Poletajew, Slawomir [1 ]
Malewski, Wojciech [1 ]
机构
[1] Ctr Postgrad Med Educ, Dept Urol 2, PL-01809 Warsaw, Poland
[2] Wroclaw Med Univ, Univ Ctr Excellence Urol, Dept Minimally Invas & Robot Urol, PL-50556 Wroclaw, Poland
[3] Pomeranian Med Univ, Dept Urol & Urol Oncol, PL-70111 Szczecin, Poland
关键词
positron emission tomography computed tomography; prostatic neoplasms; salvage therapy; predictive value of tests; sensitivity and specificity; BIOCHEMICAL RECURRENCE;
D O I
10.3390/tomography8020089
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed by salvage lymph node dissection (SLND) in three academic centers between 2013 and 2020. A total of 27 men were included in the analyses. Sensitivity, specificity, positive and negative predictive values, and accuracy of choline-PET/CT in predicting pathology-proven lymph node involvement were 75%, 43%, 79%, 38% and 67% on per-patient and 70%, 86%, 80%, 78%, and 79% on per-site analyses, respectively, with the differences in specificity and NPV between per-patient and per-site analyses being statistically significant (p = 0.03 and 0.04, respectively). The study provides further insight into the role of preoperative choline-PET/CT in patients undergoing SLND for recurrent PC.
引用
收藏
页码:1090 / 1096
页数:7
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