Antitumour activity of Bauhinia variegata against Ehrlich ascites carcinoma induced mice

被引：8
|
作者：
Rajkapoor, B
Jayakar, B
Murugesh, N
机构：
[1] Vinayaka Miss Coll Pharm, Dept Pharmacol, Salem 636008, Tamil Nadu, India
[2] Madurai Med Coll, Inst Pharmacol, Madurai 625020, Tamil Nadu, India
来源：
PHARMACEUTICAL BIOLOGY | 2003年 / 41卷 / 08期
关键词：
Bauhinia variegata; Ehrlich ascites carcinoma; heamotological sutides; in vitro cytotoxicity; life span; solid tumour;
D O I：
10.1080/13880200390501947
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The antitumour activity of ethanol extract of Bauhinia variegata (EBV) has been evaluated against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. A significant enhancement of mean survival time of EBV treated tumour bearing mice was found with respect to the control group. EBV treatment was found to enhance peritoneal cell counts. After,14 days of inoculation, EBV is able to reverse the changes in the haemotological parameters, protein and PCV consequent to tumour inoculation. Oral administration of EBV was effective in reducing solid tumour mass development induced by EAC cells. EBV was found to be a potent cytotoxic. towards EAC tumour cells.
引用
收藏
页码：604 / 607
页数：4
相关论文
共 50 条
  • [1] Antitumour activity of Terminalia arjuna leaf against Ehrlich ascites carcinoma in mice
    Biswas, Moulisha
    Bhattacharya, Sanjib
    Ghosh, Ashoke K.
    Kumar, R. B. Suresh
    Bera, Samit
    Gupta, Malaya
    Haldar, Pallab K.
    NATURAL PRODUCT RESEARCH, 2012, 26 (12) : 1141 - 1144
  • [2] Antitumour activity of Prosopis cineraria (L.) Druce against Ehrlich ascites carcinoma-induced mice
    Robertson, Stellaa
    Narayanan, N.
    Kapoor, B. Raj
    NATURAL PRODUCT RESEARCH, 2011, 25 (08) : 857 - 862
  • [3] Antitumour and antioxidant activity of Scutia myrtina against Ehrlich ascites carcinoma in Swiss albino mice
    Kumar, Ramanathan Sambath
    Kumar, Kupusamy Asok
    Murthy, Nallasamy Venkateswara
    NATURAL PRODUCT RESEARCH, 2012, 26 (16) : 1504 - 1509
  • [4] Antitumor activity and antioxident role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice
    Gupta, M
    Mazumder, UK
    Kumar, RS
    Kumar, TS
    ACTA PHARMACOLOGICA SINICA, 2004, 25 (08) : 1070 - 1076
  • [5] Antitumor activity and antioxident role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice
    Malaya GUPTA
    Upal Kanti MAZUMDER
    Ramanathan Sambath KUMAR
    Thangavel Siva KUMAR
    Acta Pharmacologica Sinica, 2004, (08) : 96 - 102
  • [6] Antitumour activity of mitoxantrone-loaded chitosan microspheres against Ehrlich ascites carcinoma
    Jameela, SR
    Latha, PG
    Subramoniam, A
    Jayakrishnan, A
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 1996, 48 (07) : 685 - 688
  • [7] Antitumour activity of Bauhinia variegata on Dalton's ascitic lymphoma
    Rajkapoor, B
    Jayakar, B
    Murugesh, N
    JOURNAL OF ETHNOPHARMACOLOGY, 2003, 89 (01) : 107 - 109
  • [8] Evaluation of antitumour activity of Calotropis gigantea L.root bark against Ehrlich ascites carcinoma in Swiss albino mice
    M Rowshahul Habib
    M Rezaul karim
    Asian Pacific Journal of Tropical Medicine, 2011, 4 (10) : 786 - 790
  • [9] Evaluation of antitumour activity of Calotropis gigantea L. root bark against Ehrlich ascites carcinoma in Swiss albino mice
    Habib, M. Rowshahul
    Karim, M. Rezaul
    ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, 2011, 4 (10) : 786 - 790
  • [10] Antitumor activity of Sansevieria roxburghiana rhizome against Ehrlich ascites carcinoma in mice
    Haldar, Pallab Kanti
    Kar, Biswakanth
    Bala, Asis
    Bhattacharya, Sanjib
    Mazumder, Upal Kanti
    PHARMACEUTICAL BIOLOGY, 2010, 48 (12) : 1337 - 1343
12345