Visible-light-mediated direct access to α-ketoamides by dealkylative amidation of tertiary amines with benzoylformic acids

被引：7
|
作者：
Zhang, Zhiguo [1 ]
Liu, Fangnan [1 ]
Chen, Jingwen [1 ]
Zhou, Kai [1 ]
Bao, Zongbi [1 ]
Su, Baogen [1 ]
Yang, Qiwei [1 ]
Ren, Qilong [1 ]
Yang, Yiwen [1 ]
机构：
[1] Zhejiang Univ, Coll Chem & Biol Engn, Minist Educ, Key Lab Biomass Chem Engn, Hangzhou 310027, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 43期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Amidation; Photoredox; alpha-Ketoamides; Visible-light; AMIDE BOND FORMATION; CATALYZED DIRECT AMIDATION; CARBOXYLIC-ACIDS; INHIBITORS; FORMAMIDES; CONVERSION;
D O I：
10.1016/j.tetlet.2019.151191
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A visible-light induced direct amidation of benzoylformic acids with tertiary amines has been explored. Tertiary amines underwent N-dealkylative amidation with alpha-keto acid in the presence of [Ir{dFCF(3)ppy)(2)(bpy)]PF6 and Cs2CO3, affording the corresponding alpha-ketoamides in good yields under mild conditions. This transformation exhibits a wide substrate scope and provides a facile synthetic approach to alpha-ketoamides. (C) 2019 Published by Elsevier Ltd.
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页数：3
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