The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors (vol 6, pg 117, 2010)

被引:2
|
作者
Berndt, Alex
Miller, Simon
Williams, Olusegun
Le, Daniel D.
Houseman, Benjamin T.
Pacold, Joseph I.
Gorrec, Fabrice
Hon, Wai-Ching
Ren, Pingda
Liu, Yi
Rommel, Christian
Gaillard, Pascale
Rueckle, Thomas
Schwarz, Matthias K.
Shokat, Kevan M.
Shaw, Jeffrey P.
Williams, Roger L.
机构
关键词
D O I
10.1038/nchembio0410-306a
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nat. Chem. Biol. 6, 117–124 (2010); published online 10 January 2010; corrected after print 12 February 2010 and 2 March 2010 In the version of this article initially published, the structure of p110δ in complex with the inhibitor IC87114 was refined with an incorrect inhibitor structure (original Protein Data Bank accession code 2WXE).
引用
收藏
页码:306 / 306
页数:1
相关论文
共 50 条
  • [41] Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils
    Rynkiewicz, Natalie K.
    Anderson, Karen E.
    Suire, Sabine
    Collins, Daniel M.
    Karanasios, Eleftherios
    Vadas, Oscar
    Williams, Roger
    Oxley, David
    Clark, Jonathan
    Stephens, Len R.
    Hawkins, Phillip T.
    [J]. SCIENCE SIGNALING, 2020, 13 (656)
  • [42] p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors
    S Fransson
    A Uv
    H Eriksson
    M K Andersson
    Y Wettergren
    M Bergo
    K Ejeskär
    [J]. Oncogene, 2012, 31 : 3277 - 3286
  • [43] Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
    Berenjeno, Inma M.
    Guillermet-Guibert, Julie
    Pearce, Wayne
    Gray, Alexander
    Fleming, Stewart
    Vanhaesebroeck, Bart
    [J]. BIOCHEMICAL JOURNAL, 2012, 442 : 151 - 159
  • [44] The PI3K Isoforms p110α and p110δ Are Essential for Pre-B Cell Receptor Signaling and B Cell Development
    Ramadani, Faruk
    Bolland, Daniel J.
    Garcon, Fabien
    Emery, Juliet L.
    Vanhaesebroeck, Bart
    Corcoran, Anne E.
    Okkenhaug, Klaus
    [J]. SCIENCE SIGNALING, 2010, 3 (134) : ra60
  • [45] p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors
    Fransson, S.
    Uv, A.
    Eriksson, H.
    Andersson, M. K.
    Wettergren, Y.
    Bergo, M.
    Ejeskar, K.
    [J]. ONCOGENE, 2012, 31 (27) : 3277 - 3286
  • [46] The P110 subunit of PI3-K is a therapeutic target of acacetin in skin cancer
    Jung, Sung Keun
    Kim, Jong Eun
    Lee, Sung-Young
    Lee, Mee Hyun
    Byun, Sanguine
    Kim, Young A.
    Lim, Tae Gyu
    Reddy, Kanamata
    Huang, Zunnan
    Bode, Ann M.
    Lee, Hyong Joo
    Lee, Ki Won
    Dong, Zigang
    [J]. CARCINOGENESIS, 2014, 35 (01) : 123 - 130
  • [47] Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer (vol 510, pg 407, 2014)
    Ali, Khaled
    Soond, Dalya R.
    Pineiro, Roberto
    Hagemann, Thorsten
    Pearce, Wayne
    Lim, Ee Lyn
    Bouabe, Hicham
    Scudamore, Cheryl L.
    Hancox, Timothy
    Maecker, Heather
    Friedman, Lori
    Turner, Martin
    Okkenhaug, Klaus
    Vanhaesebroeck, Bart
    [J]. NATURE, 2016, 535 (7613) : 580 - 580
  • [48] PI3K p110δ controls the differentiation and function of regulatory T cells
    Patton, D. T.
    Emery, J. L.
    Rowan, W. C.
    Okkenhaug, K.
    [J]. IMMUNOLOGY, 2008, 125 : 129 - 129
  • [49] Cardiac PI3K p110α attenuation delays aging and extends lifespan
    Abdellatif, Mahmoud
    Eisenberg, Tobias
    Heberle, Alexander Martin
    Thedieck, Kathrin
    Kroemer, Guido
    Sedej, Simon
    [J]. CELL STRESS, 2022, 6 (08) : 72 - 75
  • [50] PI3K p110δ expression in Merkel cell carcinoma cell lines
    Chteinberg, E.
    Rennspiess, D.
    Tauchmann, S.
    Winnepenninckx, V.
    Speel, E. -J.
    Kurz, A. K.
    Zenke, M.
    Hausen, A. Z.
    [J]. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017, 31 : 96 - 97