Practical Cancer Genetics and Genomics in Women's Health

被引：1

作者：

Modesitt, Susan ^{[1
]}

Pederson, Holly J. ^{[2
,3
]}

Adkins, Royce T. ^{[4
]}

机构：

[1] Univ Virginia, Sch Med, Dept Obstet & Gynecol, Charlottesville, VA 22908 USA

[2] Cleveland Clin, Med Breast Serv, Cleveland, OH 44106 USA

[3] Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA

[4] Myriad Womens Hlth, 320 Wakara Way, Salt Lake City, UT 84108 USA

来源：

CLINICAL OBSTETRICS AND GYNECOLOGY | 2019年 / 62卷 / 04期

关键词：

hereditary cancer; genetics; gynecologic cancer; breast cancer; HBOC; Lynch syndrome; BILATERAL PROPHYLACTIC MASTECTOMY; BREAST-CANCER; MUTATIONS; GERMLINE; OVARIAN; BRCA1; PANEL; GENES; INDIVIDUALS; PREVALENCE;

D O I：

10.1097/GRF.0000000000000480

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

There have been rapid advances in precision medicine since the Human Genome Project was completed in 2003, including several noteworthy advances in Women's Health. This includes significant advances in predicting individualized cancer risk based on hereditary cancer genetic testing, with the number of known cancer-predisposition genes extending well beyond BRCA1 and BRCA2. This has been coupled with gene-specific management guidelines for several gynecologic cancers. In addition, genetic testing can also inform therapy selection for women with gynecologic cancers. Here we address hereditary cancer and practical cancer genetics as it relates to the practicing Obstetrician/Gynecologist.

引用

页码：687 / 699

页数：13

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