Study of photodynamic activity of Au@SiO2 core-shell nanoparticles in vitro

被引：15

作者：

Meena, K. S. ^{[1
]}

Dhanalekshmi, K. I. ^{[1
]}

Jayamoorthy, K. ^{[2
]}

机构：

[1] Queen Marys Coll, PG & Res Dept Chem, Madras 600004, Tamil Nadu, India

[2] St Josephs Coll Engn, Dept Chem, Madras 600119, Tamil Nadu, India

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 63卷

关键词：

Core-shell nanoparticles; Reactive oxygen species; Photohemolysis; Cell viability; MTT assay; Photodynamic activity; OPTICAL-PROPERTIES; THERAPY; ANTIBACTERIAL; AG;

D O I：

10.1016/j.msec.2016.03.010

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Metal-semiconductor core-shell type Au@SiO2 nanoparticles were prepared by Stober's method. They were characterized by absorption, XRD, HR-TEM and EDAX techniques. The resulting modified core-shell nanoparticles shows that the formation of singlet oxygen, which was confirmed by ESR technique. The photohemolysis studies were carried out under two different experimental conditions. It is observed that the photohemolysis increases with concentration as well as light dose. Cell viability of the core-shell nanoparticles against HeLa cell lines were studied by MTT assay method. The outcomes of the present study indicate that, the Au@SiO2 core-shell nanoparticles are extremely stable with a very high photodynamic efficiency under visible light illumination. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：317 / 322

页数：6

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