Conceptual approach to the synthesis of symmetrical 1,3-diynes from β-bromo vinyl carboxylic acids

被引：3
|
作者：
Singha, Raju [1 ]
机构：
[1] Panskura Banamali Coll Autonomous, Dept Chem, Purba Medinipur 721152, W Bengal, India
来源：
JOURNAL OF CHEMICAL SCIENCES | 2019年 / 132卷 / 01期
关键词：
beta-bromo vinyl carboxylic acid; palladium; benzyne; terminal alkyne; 1,3-diyne; CROSS-COUPLING REACTION; TERMINAL ALKYNES; 1-BROMOALKYNES;
D O I：
10.1007/s12039-019-1693-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A conceptual route has been developed for the synthesis of 1,3-diyne from beta-bromo vinyl carboxylic acids. The reaction of the beta-bromo vinyl carboxylic acid with palladium catalyst is conceptually similar to the decomposition of 2-diazoniumbenzoic acid to benzyne. In the presence of palladium catalyst, the beta-bromo vinyl carboxylic acid undergoes a fragmentation to generate terminal alkyne. The terminal alkyne undergoes dimerisation in the presence of palladium catalysts to produce the product 1,3-diyne.
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页数：5
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