The first enantiomerically pure synthesis of (S)- and (R)-Naftopidil utilizing Hydrolytic Kinetic Resolution of (±)-(α-naphthyl) glycidyl ether

被引：10
|
作者：
Kothakonda, KK [1 ]
Bose, DS
机构：
[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada
[2] Chem Ind Inst Toxicol, Fine Chem Lab, Hyderabad, Andhra Pradesh, India
来源：
CHEMISTRY LETTERS | 2004年 / 33卷 / 09期
关键词：
D O I：
10.1246/cl.2004.1212
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrolytic Kinetic Resolution (HKR) of (+/-)-(alpha-Naphthyl) glycidyl ether with (R,R)-salen Co(III) OAc complex provided enatiomerically pure (S)-naphthyl glycidyl ether and (R)-1-naphthyl glycerol; opening of the corresponding pure terminal epoxide with 1-(2-methoxyphenyl)piperizine gave the enantiomerically pure (S)- and (R)-Naftopidil.
引用
收藏
页码：1212 / 1213
页数：2
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