Metal-free, base catalyzed oxidative amination and denitration reaction: Regioselective synthesis of 3-arylimidazo[1,2-a]pyridines

被引：12
|
作者：
Devi, Elango Sankari [1 ]
Alanthadka, Anitha [1 ]
Nagarajan, Subbiah [1 ,2 ]
Sridharan, Vellaisamy [1 ,3 ]
Maheswari, Chockalingam Uma [1 ]
机构：
[1] SASTRA Deemed Univ, Sch Chem & Biotechnol, Dept Chem, Organ Synth Grp, Thanjavur 613401, India
[2] Natl Inst Technol, Dept Chem, Warangal 506004, Telangana, India
[3] Cent Univ Jammu, Dept Chem & Chem Sci, Sainik Colony Sect E Extens, Temporary Acad Block, Jammu 180011, India
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 38期
关键词：
Imidazo[1,2-a]pyridines; beta-Nitrostyrenes; 2-Aminopyridines; Oxidation; Base catalysis; ONE-POT SYNTHESIS; IMIDAZOPYRIDINE; INHIBITORS; OLPRINONE;
D O I：
10.1016/j.tetlet.2018.08.024
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A metal-free, regioselective strategy for the synthesis of 3-arylimidazo[1,2-a]pyridines from beta-nitrostyrenes and 2-aminopyridines using triethylamine as the catalyst and H2O2 (30% aq.) as the oxidant is reported. The use of an inexpensive base and facile reaction conditions make this strategy a practical alternative for the synthesis of 3-arylimidazo[1,2-a]pyridines. (C) 2018 Published by Elsevier Ltd.
引用
收藏
页码：3485 / 3489
页数：5
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