Vaccines and Allergic reactions: The past, the current COVID-19 pandemic, and future perspectives

被引：78

作者：

Sampath, Vanitha ^{[1
]}

Rabinowitz, Grace ^{[1
]}

Shah, Mihir ^{[1
]}

Jain, Surabhi ^{[1
]}

Diamant, Zuzana ^{[2
,3
,4
,5
,6
]}

Jesenak, Milos ^{[7
,8
]}

Rabin, Ronald ^{[9
]}

Vieths, Stefan ^{[10
]}

Agache, Ioana ^{[11
]}

Akdis, Mubeccel ^{[12
]}

Barber, Domingo ^{[13
,14
]}

Breiteneder, Heimo ^{[15
]}

Chinthrajah, Sharon ^{[1
,16
]}

Chivato, Tomas ^{[17
]}

Collins, William ^{[1
,18
]}

Eiwegger, Thomas ^{[19
,20
,21
]}

Fast, Katharine ^{[1
]}

Fokkens, Wytske ^{[22
]}

O'Hehir, Robyn E. ^{[23
,24
]}

Ollert, Markus ^{[25
,26
,27
]}

O'Mahony, Liam ^{[28
,29
]}

Palomares, Oscar ^{[30
]}

Pfaar, Oliver ^{[31
]}

Riggioni, Carmen ^{[32
,33
]}

Shamji, Mohamed H. ^{[34
,35
]}

Sokolowska, Milena ^{[12
]}

Jose Torres, Maria ^{[36
]}

Traidl-Hoffmann, Claudia ^{[37
,38
]}

van Zelm, Menno ^{[39
,40
]}

Wang, De Yun ^{[41
]}

Zhang, Luo ^{[42
]}

Akdis, Cezmi A. ^{[12
]}

Nadeau, Kari C. ^{[1
,16
]}

机构：

[1] Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA USA

[2] Katholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, KU Leuven, Leuven, Belgium

[3] Lund Univ, Skane Univ Hosp, Inst Clin Sci, Dept Resp Med & Allergol, Lund, Sweden

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands

[5] Charles Univ Prague, Fac Med 1, Dept Resp Med, Prague, Czech Republic

[6] Thomayer Hosp, Prague, Czech Republic

[7] Comenius Univ, Univ Hosp Martin, Jessenius Fac Med Martin, Ctr Vaccinat Special Situat,Dept Pediat, Bratislava, Slovakia

[8] Comenius Univ, Univ Hosp Martin, Jessenius Fac Med Martin, Ctr Vaccinat Special Situat,Dept Clin Immunol & A, Bratislava, Slovakia

[9] US FDA, Ctr Biol Evaluat & Res, Off Vaccines Res & Review, Silver Spring, MD USA

[10] Paul Ehrlich Inst, Fed Inst Vaccines & Biomed, Langen, Germany

[11] Transylvania Univ, Brasov, Romania

[12] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Zurich, Switzerland

[13] CEU Univ, Univ San Pablo CEU, Fac Med, Inst Med Mol Aplicada IMMA,Dept CienciasMed Basic, Madrid, Spain

[14] Inst Salud Carlos III, RETIC ARADYAL, Madrid, Spain

[15] Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Dept Pathophysiol & Allergy Res, Div Med Biotechnol, Vienna, Austria

[16] Stanford Univ, Dept Med, Div Pulm & Crit Care Med, Stanford, CA 94305 USA

[17] Univ CEU San Pablo, Sch Med, Madrid, Spain

[18] Stanford Univ, Dept Med, Div Hosp Med, Stanford, CA 94305 USA

[19] Hosp Sick Children, Div Immunol & Allergy, Food Allergy & Anaphylaxis Program, Toronto, ON, Canada

[20] Hosp Sick Children, Res Inst, Translat Med, Toronto, ON, Canada

[21] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[22] Amsterdam Univ Med Ctr, Dept Otorhinolaryngol, Amsterdam, Netherlands

[23] Monash Univ, Cent Clin Sch, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia

[24] Alfred Hlth, Melbourne, Vic, Australia

[25] Luxembourg Inst Hlth, Dept Infect & Immun, Esch Sur Alzette, Luxembourg

[26] Univ Southern Denmark, Odense Univ Hosp, Odense Res Ctr Anaphylaxis, Dept Dermatol, Odense, Denmark

[27] Univ Southern Denmark, Odense Univ Hosp, Odense Res Ctr Anaphylaxis, Allergy Ctr, Odense, Denmark

[28] Univ Coll Cork, Dept Med, APC Microbiome Ireland, Cork, Ireland

[29] Univ Coll Cork, Sch Microbiol, APC Microbiome Ireland, Cork, Ireland

[30] Univ Complutense Madrid, Sch Chem, Dept Biochem & Mol Biol, Madrid, Spain

[31] Philipps Univ Marburg, Dept Otorhinolaryngol Head & Neck Surg, Sect Rhinol & Allergy, Univ Hosp Marburg, Marburg, Germany

[32] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat Allergy & Clin Immunol, Singapore, Singapore

[33] Inst Recerca St Joan de Deu, Barcelona, Spain

[34] Imperial Coll London, Dept Natl Heart & Lung Inst, Immunomodulat & Tolerance Grp, Allergy & Clin Immunol, London, England

[35] Ctr Allerg Mech Asthma, London, England

[36] Malaga Reg Univ Hosp UMA ARADyAL, Allergy Unit, Malaga, Spain

[37] Univ Augsburg, Med Fac, Dept Environm Med, Augsburg, Germany

[38] Helmholtz Zentrum Munchen, Inst Environm Med, German Res Ctr Environm Hlth, Neuherberg, Germany

[39] Monash Univ, Dept Immunol & Pathol, Melbourne, Vic, Australia

[40] Alfred Hlth, Allergy Asthma & Clin Immunol, Melbourne, Vic, Australia

[41] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Otolaryngol, Singapore, Singapore

[42] Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China

来源：

ALLERGY | 2021年 / 76卷 / 06期

关键词：

allergy; anaphylaxis; COVID-19; SARS-CoV-2; vaccine; PROTEIN-COUPLED RECEPTOR-X2; ANTI-PEG ANTIBODIES; MAST-CELL; HYPERSENSITIVITY REACTIONS; ADVERSE-REACTIONS; SAFETY DATA; ANAPHYLAXIS; VACCINATION; CHILDREN; GELATIN;

D O I：

10.1111/all.14840

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.

引用

页码：1640 / 1660

页数：21

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