MEK inhibition enhances gemcitabine efficacy by increasing MDM2-mediated ubiquitination and degradation of RRM1

被引：0
|
作者：
Vena, F. [1 ]
Li Causi, E. [2 ]
Hagemann, T. [2 ]
Hartley, J. A. [1 ]
Goodstal, S. [3 ]
Hochhauser, D. [1 ]
机构：
[1] UCL, UCL Canc Inst, London, England
[2] Barts Canc Inst, London, England
[3] EMD Serono, Res Inst, Billerica, MA USA
来源：
EUROPEAN JOURNAL OF CANCER | 2014年 / 50卷
关键词：
D O I：
10.1016/S0959-8049(14)70571-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
445
引用
收藏
页码：146 / 146
页数：1
相关论文
共 50 条
  • [11] HMGA2 promotes intestinal tumorigenesis by facilitating MDM2-mediated ubiquitination and degradation of p53
    Wang, Yuhong
    Hu, Lin
    Wang, Jian
    Li, Xiangwei
    Sahengbieke, Sana
    Wu, Jingjing
    Lai, Maode
    JOURNAL OF PATHOLOGY, 2018, 246 (04): : 508 - 518
  • [12] Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5 (vol 279, 44475, 2004)
    Dai, MS
    Lu, H
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50)
  • [13] Effect of ERK on tumorigenesis and on inhibition of FOXO3a via MDM2-mediated degradation
    Yang, J.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [14] Insulin Receptor Tyrosine Kinase Substrate Enhances Low Levels of MDM2-Mediated p53 Ubiquitination
    Wang, Ke-Sheng
    Chen, Gang
    Shen, Hai-Lian
    Li, Ting-Ting
    Chen, Fei
    Wang, Qin-Wan
    Wang, Zhi-Qin
    Han, Ze-Guang
    Zhang, Xin
    PLOS ONE, 2011, 6 (08):
  • [15] Regulation of NUB1 Activity through Non-Proteolytic Mdm2-Mediated Ubiquitination
    Bonacci, Thomas
    Audebert, Stephane
    Camoin, Luc
    Baudelet, Emilie
    Iovanna, Juan-Lucio
    Soubeyran, Philippe
    PLOS ONE, 2017, 12 (01):
  • [16] Ubiquitination of RRM1 by Ring1B (RNF2) promotes its degradation and nuclear export
    Zhang, Yingtao
    Li, Xin
    Chen, Zhengming
    Freeman, Scott
    Zhou, Jun
    Bepler, Gerold
    CANCER RESEARCH, 2011, 71
  • [17] The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation
    Louria-Hayon, I
    Grossman, T
    Sionov, RV
    Alsheich, O
    Pandolfi, PP
    Haupt, Y
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (35) : 33134 - 33141
  • [18] Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination
    Yan, Jing
    Di, Yujun
    Shi, Huili
    Rao, Hai
    Huo, Keke
    FEBS LETTERS, 2010, 584 (20) : 4319 - 4324
  • [19] The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy-Letter
    Leon, Leticia G.
    Funel, Niccola
    Peters, Godefridus J.
    Avan, Amir
    Vistoli, Fabio
    Boggi, Ugo
    Giovannetti, Elisa
    CLINICAL CANCER RESEARCH, 2016, 22 (10) : 2594 - 2594
  • [20] Epstein-Barr Virus Nuclear Antigen 3C Augments Mdm2-Mediated p53 Ubiquitination and Degradation by Deubiquitinating Mdm2
    Saha, Abhik
    Murakami, Masanao
    Kumar, Pankaj
    Bajaj, Bharat
    Sims, Karen
    Robertson, Erle S.
    JOURNAL OF VIROLOGY, 2009, 83 (09) : 4652 - 4669
12345