The SRC/ABL inhibitor BMS-354825 overcomes resistance to imatinib mesylate in chronic myelogenous leukemia cells through multiple mechanisms.

被引:4
|
作者
Donato, NJ
Wu, J
Kong, LY
Lee, F
Talpaz, M
机构
[1] MD Anderson Canc Ctr, Houston, TX USA
[2] Bristol Myers Squibb, Canc Therapeut, Princeton, NJ USA
关键词
D O I
10.1182/blood.V104.11.1989.1989
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1989
引用
收藏
页码:549A / 549A
页数:1
相关论文
共 50 条
  • [41] The dual SRC/ABL kinase inhibitor SKI-606 effectively inhibits BCR-ABL kinase activity in chronic myelogenous leukemia primitive progenitor cells.
    Sindhu, S.
    Koenig, H.
    Boschelli, F.
    Holyoake, T. L.
    Forman, S. J.
    Bhatia, R.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2007, 55 (01) : S141 - S141
  • [42] Insights from pre-clinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia: a translational perspective
    P La Rosée
    ME O'Dwyer
    BJ Druker
    Leukemia, 2002, 16 : 1213 - 1219
  • [43] Insights from pre-clinical studies for new combination treatment regimens with the Bcr-Abl kinase inhibitor imatinib mesylate (Gleevec/Glivec) in chronic myelogenous leukemia:: a translational perspective
    La Rosée, P
    O'Dwyer, ME
    Druker, BJ
    LEUKEMIA, 2002, 16 (07) : 1213 - 1219
  • [44] Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells
    Yin, Yue
    Sun, Huiyan
    Xu, Jun
    Xiao, Fengjun
    Wang, Hua
    Yang, Yuefeng
    Ren, Hanyun
    Wu, Chu-Tse
    Gao, Chunji
    Wang, Lisheng
    LEUKEMIA & LYMPHOMA, 2015, 56 (06) : 1813 - 1820
  • [45] Modulation of P-glycoprotein and proinflammatory cytokines with HMG-CoA reductase inhibitor simvastatin (SV) in chronic myelogenous leukemia (CML) patients with imatinib mesylate (IM) resistance
    McPherson, E.
    Hazel, E.
    Tassy, P.
    Kleinfeld, J.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [46] JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia
    Aranda-Tavio, Haidee
    Recio, Carlota
    Martin-Acosta, Pedro
    Guerra-Rodriguez, Miguel
    Brito-Casillas, Yeray
    Blanco, Rosa
    Junco, Vanessa
    Leon, Javier
    Carlos Montero, Juan
    Gandullo-Sanchez, Lucia
    McNaughton-Smith, Grant
    Manuel Zapata, Juan
    Pandiella, Atanasio
    Amesty, Angel
    Estevez-Braun, Ana
    Fernandez-Perez, Leandro
    Guerra, Borja
    BIOMEDICINE & PHARMACOTHERAPY, 2021, 144
  • [47] Results of imatinib mesylate (STI571), a bcr-abl tyrosine kinase inhibitor, in Philadelphia chromosome-positive chronic myelogenous leukemia in blastic phase (Ph plus CML BP).
    Kantarjian, HM
    Cortes, J
    O'Brien, S
    Giles, F
    Albitar, M
    Rios, MB
    Shan, J
    Faderl, S
    Garcia-Manero, G
    Issa, JP
    Thomas, D
    Capdeville, R
    Talpaz, M
    BLOOD, 2001, 98 (11) : 260B - 260B
  • [48] Inhibition of BCR-ABL signaling in imatinib sensitive and resistant chronic myelogenous leukemia and progenitor cells through small molecule-mediated BCR-ABL ubiquitination and aggresomal deposition
    Donato, Nicholas
    Sun, Hanshi
    Kapuria, Vaibhav
    Peterson, Luke
    Peng, Zhenghong
    Maxwell, David
    Bornmann, William
    Talpaz, Moshe
    CANCER RESEARCH, 2009, 69
  • [49] Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells
    Nimmanapalli, R
    Fuino, L
    Bali, P
    Gasparetto, M
    Glozak, M
    Tao, JG
    Moscinski, L
    Smith, C
    Wu, J
    Jove, R
    Atadja, P
    Bhalla, K
    CANCER RESEARCH, 2003, 63 (16) : 5126 - 5135
  • [50] Persistent Activation of the Fyn/ERK Kinase Signaling Axis Mediates Imatinib Resistance in Chronic Myelogenous Leukemia Cells through Upregulation of Intracellular SPARC
    Fenouille, Nina
    Puissant, Alexandre
    Dufies, Maeva
    Robert, Guillaume
    Jacquel, Arnaud
    Ohanna, Mickael
    Deckert, Marcel
    Pasquet, Jean-Max
    Mahon, Francois-Xavier
    Cassuto, Jill-Patrice
    Raynaud, Sophie
    Tartare-Deckert, Sophie
    Auberger, Patrick
    CANCER RESEARCH, 2010, 70 (23) : 9659 - 9670