Synthesis and Cytotoxic Activity of Lupane Triterpenoids Containing 1,3,4-Oxadiazoles

被引：14
|
作者：
Antimonova, A. N. [1 ]
Petrenko, N. I. [1 ]
Shakirov, M. M. [1 ]
Pokrovskii, M. A. [2 ]
Pokrovskii, A. G. [2 ]
Shul'ts, E. E. [1 ]
机构：
[1] Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia
[2] Novosibirsk State Natl Res Univ, Novosibirsk 630090, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 06期
关键词：
betulonic and betulinic acids; hydrazides; 1,3,4-oxadiazoles; cytotoxic activity; DERIVATIVES; INHIBITION; FRAGMENTS;
D O I：
10.1007/s10600-014-1150-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New derivatives of betulonic and betulinic acids with 1,3,4-oxadiazole substituents in the C-17 position were prepared. The cytotoxic activity of the betulonic acid derivatives was studied using MT-4, CEM-13, and U-937 human tumor cell models.
引用
收藏
页码：1016 / 1023
页数：8
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