Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium oxalicum: Structural Elucidation and Total Synthesis

被引：22
|
作者：
Yang, Zheng [1 ]
Huang, Nianyu [1 ]
Xu, Bang [1 ,2 ,3 ]
Huang, Wenfeng [4 ]
Xie, Tianpeng [1 ]
Cheng, Fan [1 ]
Zou, Kun [1 ]
机构：
[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
[2] China Three Gorges Univ Peoples Hosp, Yichang 443000, Peoples R China
[3] Yichang First Peoples Hosp, Yichang 443000, Peoples R China
[4] China Three Gorges Univ, Coll Med, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China
来源：
MOLECULES | 2016年 / 21卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Penicillium oxalicum; alkaloids; total synthesis; structure elucidation; cytotoxicity; IMMUNOSUPPRESSIVE POLYKETIDES; DALDINIA-ESCHSCHOLZII; MYXOCOCCUS-FULVUS; FUNGUS; 1,3,4-THIADIAZOLE; INHIBITORS; GLUCOSIDE; CANCER; ANALOG;
D O I：
10.3390/molecules21030232
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new thiazole and thiadiazole alkaloids, penicilliumthiamine A and B (2 and 3), were isolated from the culture broth of Penicillium oxalicum, a fungus found in Acrida cinerea. Their structures were elucidated mainly by spectroscopic analysis, total synthesis and X-ray crystallographic analysis. Biological evaluations indicated that compound 1, 3a and 3 exhibit potent cytotoxicity against different cancer cell lines through inhibiting the phosphorylation of AKT/PKB (Ser 473), one of important cancer drugs target.
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页数：12
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