Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium oxalicum: Structural Elucidation and Total Synthesis

被引：22

作者：

Yang, Zheng ^{[1
]}

Huang, Nianyu ^{[1
]}

Xu, Bang ^{[1
,2
,3
]}

Huang, Wenfeng ^{[4
]}

Xie, Tianpeng ^{[1
]}

Cheng, Fan ^{[1
]}

Zou, Kun ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

[2] China Three Gorges Univ Peoples Hosp, Yichang 443000, Peoples R China

[3] Yichang First Peoples Hosp, Yichang 443000, Peoples R China

[4] China Three Gorges Univ, Coll Med, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

来源：

MOLECULES | 2016年 / 21卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Penicillium oxalicum; alkaloids; total synthesis; structure elucidation; cytotoxicity; IMMUNOSUPPRESSIVE POLYKETIDES; DALDINIA-ESCHSCHOLZII; MYXOCOCCUS-FULVUS; FUNGUS; 1,3,4-THIADIAZOLE; INHIBITORS; GLUCOSIDE; CANCER; ANALOG;

D O I：

10.3390/molecules21030232

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new thiazole and thiadiazole alkaloids, penicilliumthiamine A and B (2 and 3), were isolated from the culture broth of Penicillium oxalicum, a fungus found in Acrida cinerea. Their structures were elucidated mainly by spectroscopic analysis, total synthesis and X-ray crystallographic analysis. Biological evaluations indicated that compound 1, 3a and 3 exhibit potent cytotoxicity against different cancer cell lines through inhibiting the phosphorylation of AKT/PKB (Ser 473), one of important cancer drugs target.

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页数：12

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