The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

被引：402

作者：

Wolfson, Rachel L. ^{[1
,2
,3
,4
,5
]}

Sabatini, David M. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Whitehead Inst Biomed Res, 455 Main St, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] MIT, Howard Hughes Med Inst, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[4] MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[5] Broad Inst, 415 Main St, Cambridge, MA 02142 USA

来源：

CELL METABOLISM | 2017年 / 26卷 / 02期

关键词：

GTP-BINDING PROTEINS; RAG GTPASES; TUMOR-SUPPRESSOR; MAMMALIAN TARGET; GAP ACTIVITY; IDENTIFICATION; SESTRINS; COMPLEX; GENE; METABOLISM;

D O I：

10.1016/j.cmet.2017.07.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors.

引用

页码：301 / 309

页数：9

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