Advances in Microfluidic Organ-on-a-Chip Systems

Organ-on-a-chip systems aim to build integrated microsystems to simulate human tissue and organ functions by utilizing the control ability of microfluidic chips to microfluids , cells and their micro-environment, for providing low-cost screening and research models close to in-vivo physiological and pathological conditions for evaluation of effectiveness and biosafety of drugs and vaccines, as well as biomedical research. In this review , the progress of organ-on-a-chip systems based on channels , chambers and membranes are introduced according to their structures and cell culturing modes.