Discovery of FAK Inhibitors Using Structure Based Drug Design

被引：1
|
作者：
Nam, Ky-Youb [1 ]
Jin, Dong-Hoon [2 ]
No, Kyoung Tai [3 ]
Ahn, Soon Kil [4 ]
机构：
[1] Asan Med Ctr, Ctr Dev & Commercializat Anticanc Therapeut, Seoul 138736, South Korea
[2] Univ Ulsan Coll Med, Asan Med Ctr, Dept Convergence Med, Asan Inst Life Sci, Seoul 138736, South Korea
[3] Yonsei Univ, Dept Biotechnol, Seoul 120749, South Korea
[4] Incheon Natl Univ, Div Life Sci, Inst New Drug Dev, Inchon 406772, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2014年 / 35卷 / 11期
关键词：
Focal adhesion kinase 1; Kinase inhibitor; Anticancer drug; Quantum mechanical calculations; Structure-based drug design; FOCAL ADHESION KINASE; HUMAN BREAST; PREDICTION; TISSUES;
D O I：
10.5012/bkcs.2014.35.11.3156
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：3156 / 3157
页数：2
相关论文
共 50 条
  • [1] Fragment based drug discovery of allosteric FAK inhibitors
    Cossio, Osvaldo
    Campos-Olivas, Ramon
    Santiveri Martin-Vares, Clara
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [2] Discovery of novel α-amylase inhibitors using structure-based drug design
    Jamil Al-Asri
    Gerhard Wolber
    [J]. Journal of Cheminformatics, 6 (Suppl 1)
  • [3] Discovery of novel Myc inhibitors using structure and ligand-based drug design
    Liosi, Maria-Elena
    Stellas, Dimitris
    Efstratiadis, Argiris
    Cournia, Zoe
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [4] Structure based drug design and discovery of iminopyrimidinones as potent renin inhibitors
    Khan, Tanweer A.
    Mckittrick, Brian A.
    Orth, Peter
    Wang, Hongwu
    Strickland, Corey
    Voigt, Johannes
    Hubert, Josien
    Caldwel, John
    Vaccaro, Henry A.
    Rajagopalan, Murali
    Bara, Thomas
    Hong, Liwu
    Mazzola, Robert D.
    Huang, Ying
    Iserloh, Ulrich
    Wong, Jesse
    Liang, Mark
    Heap, Charles
    Zych, Andrew
    Courneya, Brandy
    Fleming, Linda
    Giessert, Rachel
    Mitra, Shomo
    Roy, Sudipta
    Sakwa, Samuel
    Duffy, Ruth
    Chintala, Madhu
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [5] Discovery of novel orally bioavailable renin inhibitors by structure based drug design
    Edmunds, Jeremy J.
    Belliotti, Thomas
    Bryant, John
    Cai, Cuiman
    Cheng, Xue Min
    Ciske, Fred L.
    Cody, Wayne L.
    Collard, Wendy
    Downing, Dennis M.
    Erasga, Noe
    Ferreira, Suzie
    Hall, Eric
    Holsworth, Daniel D.
    Jalaie, Mehran
    Kasani, Aparna
    Kaufman, Michael
    Lee, Chitase
    Li, Tingsheng
    Maiti, Samarendra
    McConnell, Patrick
    Mennen, Ken
    Ostroski, Robert
    Powell, Noel A.
    Quinn, John, III
    Rahim, Mohammad
    Ryan, Michael
    Stier, Michael A.
    Subedi, Rajandra
    Van Huis, Chad
    Zhang, Erli
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [6] Structure-based discovery of cellular-active allosteric inhibitors of FAK
    Tomita, Naoki
    Hayashi, Yoko
    Suzuki, Shinkichi
    Oomori, Yoshimasa
    Aramaki, Yoshio
    Matsushita, Yoshihiro
    Iwatani, Misa
    Iwata, Hidehisa
    Okabe, Atsutoshi
    Awazu, Yoshiko
    Isono, Osamu
    Skene, Robert J.
    Hosfield, David J.
    Miki, Hiroshi
    Kawamoto, Tomohiro
    Hori, Akira
    Baba, Atsuo
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (06) : 1779 - 1785
  • [7] Discovery of novel dual acetylcholinesterase and butyrylcholinesterase inhibitors using machine learning and structure-based drug design
    Tripathi, Manish Kumar
    Bhardwaj, Bhagwati
    Waiker, Digambar Kumar
    Tripathi, Avanish
    Shrivastava, Sushant Kumar
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2023, 1286
  • [8] DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESIGN
    Baifeng ZHENG
    Yaochao YAN
    Can FU
    Guangyi HUANG
    Long ZHAO
    Qiong CHEN
    Renyu QU
    Guangfu YANG
    [J]. Frontiers of Agricultural Science and Engineering, 2022, (01) : 133 - 145
  • [9] DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESIGN
    Zheng, Baifeng
    Yan, Yaochao
    Fu, Can
    Huang, Guangyi
    Zhao, Long
    Chen, Qiong
    Qu, Renyu
    Yang, Guangfu
    [J]. FRONTIERS OF AGRICULTURAL SCIENCE AND ENGINEERING, 2022, 9 (01) : 133 - 145
  • [10] Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods
    Higgins, William T.
    Vibhute, Sandip
    Bennett, Chad
    Lindert, Steffen
    [J]. JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 64 (02) : 435 - 448
12345