Adrenergic Receptor Polymorphisms in Heart Failure: what Can Genetics Explain?

被引：4

作者：

Pereira, Sabrina Bernardez ^{[1
]}

Gava, Isabela Ambrosio ^{[1
]}

Giro, Camila ^{[1
]}

Mesquita, Evandro Tinoco ^{[1
]}

机构：

[1] Univ Fed Fluminense, Rio De Janeiro, Brazil

来源：

ARQUIVOS BRASILEIROS DE CARDIOLOGIA | 2010年 / 94卷 / 06期

关键词：

BETA(2)-ADRENERGIC RECEPTOR; BETA(1)-ADRENERGIC RECEPTOR; BETA-2-ADRENOCEPTOR POLYMORPHISMS; THR164ILE POLYMORPHISM; DESENSITIZATION; ASSOCIATION; RESPONSES; RISK; BETA-1-ADRENOCEPTOR; SURVIVAL;

D O I：

10.1590/S0066-782X2010000600019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure (HF) is a complex disease, which involves several physiopathological mechanisms and different genetic polymorphisms. The adrenergic system is directly related to this pathology, as it participates in cardiovascular autoregulation and has a crucial role in the deterioration of cardiac function. The beta-blockers appeared as a great advance in cardiology for the treatment of HF; however, the drug response varies according to each patient, as several factors are associated, such as the genetic one. This review aims at assessing the genetic involvement in the development of HF, the drug response and the prognosis.

引用

页码：841 / 849

页数：9

共 50 条

[21] The β-adrenergic receptor kinase in heart failure
Petrofski, JA
Koch, WJ
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2003, 35 (10) : 1167 - 1174
[22] Polymorphisms of adrenergic receptors and the risk of heart failure - Reply
Kardia, SLR
Levin, AM
Liggett, SB
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (05): : 470 - 470
[23] What is the role of β-adrenergic signaling in heart failure?
Lohse, MJ
Engelhardt, S
Eschenhagen, T
CIRCULATION RESEARCH, 2003, 93 (10) : 896 - 906
[24] Interactions between β1 and β2 adrenergic receptor polymorphisms as risk factors for chronic heart failure
Moraga, Francisco
Troncoso, Rodrigo
Mellado, Rosemarie
Diaz-Araya, Guillermo
Luis Vukasovic, Jose
Greig, Douglas
Perez, Osvaldo
Garcia, Lorena
Roldan, Juan
Paz Ocaranza, Maria
Jalil, Jorge
Chiong, Mario
Castro, Pablo
REVISTA MEDICA DE CHILE, 2008, 136 (11) : 1371 - 1380
[25] Beta1-adrenergic Receptor Polymorphisms Associated with Atrial Fibrillation in Systolic Heart Failure
do Nascimento, Bruno Costa
Pereira, Sabrina Bernandez
Ribeiro, Georgina Severo
Mesquita, Evandro Tinoco
ARQUIVOS BRASILEIROS DE CARDIOLOGIA, 2012, 98 (05) : 384 - 389
[26] Alterations in adrenergic receptor signaling in heart failure
Lamba S.
Abraham W.T.
Heart Failure Reviews, 2000, 5 (1) : 7 - 16
[27] β-adrenergic receptor blockade in chronic heart failure
Bristow, MR
CIRCULATION, 2000, 101 (05) : 558 - 569
[28] β-adrenergic receptors and receptor signaling in heart failure
Post, SR
Hammond, HK
Insel, PA
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 : 343 - 360
[29] Common beta adrenergic receptor polymorphisms and the progression of heart failure following first acute myocardial infarction
Szelid, Zsolt L.
Lux, Arpad
Soos, Pal
Bagyura, Zsolt
Veress, Gabriella
Merkely, Bela
CIRCULATION, 2012, 125 (19) : E690 - E690
[30] Beta2-adrenergic receptor polymorphisms predict heart failure progression in idiopathic dilated cardiomyopathy
Forleo, C
Resta, N
Sorrentino, S
Guida, P
Manghisi, A
De Luca, V
Romito, R
Iacoviello, M
Massari, F
Rizzon, B
Guanti, G
Rizzon, P
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (06) : 201A - 201A

← 1 2 3 4 5 →