Adrenergic Receptor Polymorphisms in Heart Failure: what Can Genetics Explain?

被引：4
|
作者：
Pereira, Sabrina Bernardez [1 ]
Gava, Isabela Ambrosio [1 ]
Giro, Camila [1 ]
Mesquita, Evandro Tinoco [1 ]
机构：
[1] Univ Fed Fluminense, Rio De Janeiro, Brazil
来源：
ARQUIVOS BRASILEIROS DE CARDIOLOGIA | 2010年 / 94卷 / 06期
关键词：
BETA(2)-ADRENERGIC RECEPTOR; BETA(1)-ADRENERGIC RECEPTOR; BETA-2-ADRENOCEPTOR POLYMORPHISMS; THR164ILE POLYMORPHISM; DESENSITIZATION; ASSOCIATION; RESPONSES; RISK; BETA-1-ADRENOCEPTOR; SURVIVAL;
D O I：
10.1590/S0066-782X2010000600019
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heart failure (HF) is a complex disease, which involves several physiopathological mechanisms and different genetic polymorphisms. The adrenergic system is directly related to this pathology, as it participates in cardiovascular autoregulation and has a crucial role in the deterioration of cardiac function. The beta-blockers appeared as a great advance in cardiology for the treatment of HF; however, the drug response varies according to each patient, as several factors are associated, such as the genetic one. This review aims at assessing the genetic involvement in the development of HF, the drug response and the prognosis.
引用
收藏
页码：841 / 849
页数：9
相关论文
共 50 条
  • [1] Adrenergic-receptor polymorphisms and heart failure
    Hajjar, RJ
    MacRae, CA
    NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (15): : 1196 - 1199
  • [2] The role of adrenergic receptor polymorphisms in heart failure
    Biolo, A.
    Rosa, A. S.
    Mazzotti, N. G.
    Martins, S.
    Bello-Klein, A.
    Rohde, L. E.
    Clausell, N.
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2006, 39 (10) : 1281 - 1290
  • [3] β-Adrenergic Receptor Gene Polymorphisms and its Relationship with Heart Failure
    Kolovou, Genovefa
    Kolovou, Vana
    Mavrogeni, Sophie
    CURRENT VASCULAR PHARMACOLOGY, 2018, 16 (06) : 624 - 625
  • [4] β2-adrenergic receptor polymorphisms are not associated with heart failure
    Lavandero, S
    Moraga, F
    Mario, C
    Diaz-Araya, G
    Vukasovic, JL
    Pablo, C
    Pérez, O
    Moreno, M
    Ocaranza, MP
    Jalil, J
    Ivonne, P
    Nazal, C
    Corbalán, R
    FASEB JOURNAL, 2002, 16 (04): : A587 - A587
  • [5] Polymorphisms of β-adrenergic receptors in heart failure
    Liggett, SB
    AMERICAN JOURNAL OF MEDICINE, 2004, 117 (07): : 525 - 527
  • [6] Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with heart failure
    Sauer, William
    Lowery, Christopher M.
    Budhathoki, Chakra
    Lowes, Brian D.
    Bristow, Michael R.
    CIRCULATION, 2007, 116 (16) : 437 - 437
  • [7] β1 and β2-adrenergic receptor gene polymorphisms are not associated with heart failure
    Lavandero, S
    Moraga, F
    Mellado, R
    Chiong, M
    Diaz-Araya, G
    Castro, P
    Greig, D
    Perez, O
    Moreno, M
    FASEB JOURNAL, 2003, 17 (04): : A652 - A652
  • [8] Polymorphisms of the β1-adrenergic receptor predict exercise capacity in heart failure
    Wagoner, LE
    Craft, LL
    Zengel, P
    McGuire, N
    Rathz, DA
    Dorn, GW
    Liggett, SB
    AMERICAN HEART JOURNAL, 2002, 144 (05) : 840 - 846
  • [9] Polymorphisms of adrenergic receptors and the risk of heart failure
    Little, J
    Gwinn, M
    Khoury, M
    NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (05): : 469 - 470
  • [10] Role of β adrenergic receptor polymorphisms in heart failure:: Systematic review and meta-analysis
    Muthumala, Amal
    Drenos, Fotios
    Elliott, Perry M.
    Humphries, Steve E.
    EUROPEAN JOURNAL OF HEART FAILURE, 2008, 10 (01) : 3 - 13
12345