Model selection in the weighted generalized estimating equations for longitudinal data with dropout

被引:9
|
作者
Gosho, Masahiko [1 ,2 ]
机构
[1] Aichi Med Univ, Adv Med Res Ctr, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan
[2] Univ Tsukuba, Fac Med, Dept Clin Trial & Clin Epidemiol, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan
关键词
Correlation structure; Missingness; Quasi-likelihood; Robust variance; WORKING-CORRELATION-STRUCTURE; LINEAR-MODELS; MISSING DATA; BINARY DATA; INFORMATION CRITERION; VARIABLE SELECTION; EFFICIENCY; INFERENCE; GEE;
D O I
10.1002/bimj.201400045
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We propose criteria for variable selection in the mean model and for the selection of a working correlation structure in longitudinal data with dropout missingness using weighted generalized estimating equations. The proposed criteria are based on a weighted quasi-likelihood function and a penalty term. Our simulation results show that the proposed criteria frequently select the correct model in candidate mean models. The proposed criteria also have good performance in selecting the working correlation structure for binary and normal outcomes. We illustrate our approaches using two empirical examples. In the first example, we use data from a randomized double-blind study to test the cancer-preventing effects of beta carotene. In the second example, we use longitudinal CD4 count data from a randomized double-blind study.
引用
收藏
页码:570 / 587
页数:18
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