Recent advances in the applications of metabolomics in eye research

被引：22

作者：

Chen, Liyan ^{[1
]}

Gao, Yan ^{[1
]}

Wang, Louis Zizhao ^{[1
,2
]}

Cheung, Ning ^{[3
]}

Tan, Gavin S. W. ^{[3
]}

Cheung, Gemmy Chiu Ming ^{[3
]}

Beuerman, Roger W. ^{[1
,4
,5
]}

Wong, Tien Yin ^{[1
,3
,4
,5
]}

Chan, Eric Chun Yong ^{[6
]}

Zhou, Lei ^{[1
,4
,5
]}

机构：

[1] Singapore Eye Res Inst, Singapore, Singapore

[2] Natl Univ Hlth Syst, Natl Univ Hosp, Dept Ophthalmol, Singapore, Singapore

[3] Singapore Natl Eye Ctr, Singapore, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore

[5] Duke NUS Grad Med Sch, Ophthalmol & Visual Sci Acad Clin Res Program, Singapore, Singapore

[6] Natl Univ Singapore, Dept Pharm, Fac Sci, Singapore, Singapore

来源：

ANALYTICA CHIMICA ACTA | 2018年 / 1037卷

基金：

英国医学研究理事会;

关键词：

Metabolomics; Eye disease; LC-MS/MS; NMR; Metabolite; POLYPOIDAL CHOROIDAL VASCULOPATHY; RHEGMATOGENOUS RETINAL-DETACHMENT; HUMOR COMPARATIVE PROFILES; HUMAN TRABECULAR MESHWORK; AQUEOUS-HUMOR; MACULAR DEGENERATION; DIABETIC-RETINOPATHY; GLOBAL PREVALENCE; MASS-SPECTROMETRY; RISK-FACTORS;

D O I：

10.1016/j.aca.2018.01.060

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Metabolomics, the identification and quantitation of metabolites in a system, have been applied to identify new biomarkers or elucidate disease mechanism. In this review, we discussed the application of metabolomics in several ocular diseases and recent developments in metabolomics regarding tear fluids analysis, data acquisition and processing. (c) 2018 Elsevier B.V. All rights reserved.

引用

页码：28 / 40

页数：13

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