Indirect Enantioseparations: Recent Advances in Chiral Metabolomics for Biomedical Research

被引：8

作者：

Bogos, Luisa-Gabriela ^{[1
,2
]}

Pralea, Ioana-Ecaterina ^{[1
]}

Moldovan, Radu-Cristian ^{[1
]}

Iuga, Cristina-Adela ^{[1
,2
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Res Ctr Adv Med MEDFUTURE, Dept Prote & Metab, Louis Pasteur St 6, Cluj Napoca 400349, Romania

[2] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Anal, Louis Pasteur St 6, Cluj Napoca 400349, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 13期

关键词：

chiral metabolomics; indirect chiral analysis; chiral derivatization agents; endogenous metabolites; mass spectrometry metabolomics; ion-mobility mass spectrometry; D-AMINO ACIDS; PERFORMANCE-LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; ION MOBILITY SPECTROMETRY; LC-ESI-MS/MS; TRIAZOLE-BONDED COLUMN; PRECOLUMN DERIVATIZATION; CARBOXYLIC-ACIDS; D-SERINE; (-)-1-(9-FLUORENYL)ETHYL CHLOROFORMATE;

D O I：

10.3390/ijms23137428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chiral metabolomics is starting to become a well-defined research field, powered by the recent advances in separation techniques. This review aimed to cover the most relevant advances in indirect enantioseparations of endogenous metabolites that were published over the last 10 years, including improvements and development of new chiral derivatizing agents, along with advances in separation methodologies. Moreover, special emphasis is put on exciting advances in separation techniques combined with mass spectrometry, such as chiral discrimination by ion-mobility mass spectrometry together with untargeted strategies for profiling of chiral metabolites in complex matrices. These advances signify a leap in chiral metabolomics technologies that will surely offer a solid base to better understand the specific roles of enantiomeric metabolites in systems biology.

引用

页数：29

共 50 条

[1] Recent advances in electrodriven enantioseparations
Jac, Pavel
Scriba, Gerhard K. E.
[J]. JOURNAL OF SEPARATION SCIENCE, 2013, 36 (01) : 52 - 74
[2] Recent Advances in Chiral Plasmonics - Towards Biomedical Applications
Kumar, Jatish
Liz-Marzan, Luis M.
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2019, 92 (01) : 30 - 37
[3] Recent advances in the applications of metabolomics in eye research
Chen, Liyan
Gao, Yan
Wang, Louis Zizhao
Cheung, Ning
Tan, Gavin S. W.
Cheung, Gemmy Chiu Ming
Beuerman, Roger W.
Wong, Tien Yin
Chan, Eric Chun Yong
Zhou, Lei
[J]. ANALYTICA CHIMICA ACTA, 2018, 1037 : 28 - 40
[4] Recent advances in enantioseparations of peptides by capillary electrophoresis
Scriba, GKE
[J]. ELECTROPHORESIS, 2003, 24 (22-23) : 4063 - 4077
[5] Recent advances in the use of gelatin in biomedical research
Kai Su
Chunming Wang
[J]. Biotechnology Letters, 2015, 37 : 2139 - 2145
[6] Recent advances in the use of gelatin in biomedical research
Su, Kai
Wang, Chunming
[J]. BIOTECHNOLOGY LETTERS, 2015, 37 (11) : 2139 - 2145
[7] Recent Advances in Metabolomics
Smith, Robert E.
Tran, Kevin
Richards, Kristy M.
[J]. CURRENT METABOLOMICS, 2015, 3 (01) : 54 - 64
[8] Recent advances of enantioseparations in capillary electrophoresis and capillary electrochromatography
Lu, Huang
Chen, Guonan
[J]. ANALYTICAL METHODS, 2011, 3 (03) : 488 - 508
[9] RECENT ADVANCES IN BIOMEDICAL-RESEARCH IN SCHIZOPHRENIA - INTRODUCTION
FRIEDEL, RO
[J]. PSYCHOPHARMACOLOGY BULLETIN, 1986, 22 (03) : 917 - 917
[10] Metabolomics in drug research and development: The recent advances in technologies and applications
Huanhuan Pang
Zeping Hu
[J]. Acta Pharmaceutica Sinica B, 2023, (08) : 3238 - 3251

← 1 2 3 4 5 →