Transgenic Mouse Models of SV40-Induced Cancer

被引：11
|
作者：
Hudson, Amanda L. [1 ]
Colvin, Emily K. [1 ]
机构：
[1] Univ Sydney, Bill Walsh Translat Canc Res Lab, Sydney Med Sch Northern, Kolling Inst,Northern Sydney Local Hlth Dist, St Leonards, NSW, Australia
来源：
ILAR JOURNAL | 2016年 / 57卷 / 01期
关键词：
cancer; mouse model; SV40; transgenic; SIMIAN-VIRUS-40; T-ANTIGEN; LARGE TUMOR-ANTIGEN; VILLUS-ASSOCIATED ENTEROCYTES; TRANSITIONAL-CELL CARCINOMA; GROWTH-FACTOR RECEPTOR; HEPATOCELLULAR-CARCINOMA; MAMMARY-CANCER; IN-SITU; REGULATORY ELEMENTS; INTRAOCULAR TUMORS;
D O I：
10.1093/ilar/ilw001
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The SV40 viral oncogene has been used since the 1970s as a reliable and reproducible method to generate transgenic mouse models. This seminal discovery has taught us an immense amount about how tumorigenesis occurs, and its success has led to the evolution of many mouse models of cancer. Despite the development of more modern and targeted approaches for developing genetically engineered mouse models of cancer, SV40-induced mouse models still remain frequently used today. This review discusses a number of cancer types in which SV40 mouse models of cancer have been developed and highlights their relevance and importance to preclinical research.
引用
收藏
页码：44 / 54
页数：11
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