Quantification of Familial Risk of Nasopharyngeal Carcinoma in a High-Incidence Area

被引:67
|
作者
Liu, Zhiwei [1 ]
Chang, Ellen T. [2 ,3 ]
Liu, Qing [4 ,5 ]
Cai, Yonglin [6 ,7 ]
Zhang, Zhe [8 ,9 ]
Chen, Guomin [10 ]
Huang, Qi-Hong [11 ]
Xie, Shang-Hang [4 ,5 ]
Cao, Su-Mei [4 ,5 ]
Shao, Jian-Yong [5 ]
Jia, Wei-Hua [5 ]
Zheng, Yuming [6 ,7 ]
Liao, Jian [12 ]
Chen, Yufeng [9 ]
Lin, Longde [9 ]
Liang, Liming [13 ,14 ]
Ernberg, Ingemar [15 ]
Vaughan, Thomas L. [16 ,17 ]
Adami, Hans-Olov [1 ,13 ]
Huang, Guangwu [8 ,9 ]
Zeng, Yi [10 ]
Zeng, Yi-Xin [5 ,18 ]
Ye, Weimin [1 ]
机构
[1] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden
[2] Exponent Inc, Hlth Sci Practice, Menlo Pk, CA USA
[3] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Div Epidemiol, Stanford, CA 94305 USA
[4] Sun Yat Sen Univ, Canc Ctr, Dept Canc Prevent Ctr, Guangzhou, Guangdong, Peoples R China
[5] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol S China, Guangzhou, Guangdong, Peoples R China
[6] Wuzhou Red Cross Hosp, Dept Clin Lab, Wuzhou, Guangxi, Peoples R China
[7] Wuzhou Hlth Syst Key Lab Nasopharyngeal Carcinoma, Wuzhou, Guangxi, Peoples R China
[8] Guangxi Med Univ, Affiliated Hosp 1, Dept Otolaryngol Head & Neck Surg, Nanning, Guangxi, Peoples R China
[9] Guangxi Med Univ, Minist Educ, Key Lab High Incidence Tumor Prevent & Treatment, Nanning, Guangxi, Peoples R China
[10] Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing, Peoples R China
[11] Sihui Canc Inst, Sihui, Guangdong, Peoples R China
[12] Cangwu Inst Nasopharyngeal Carcinoma Control & Pr, Wuzhou, Guangxi, Peoples R China
[13] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[14] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
[15] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
[16] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA
[17] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[18] Beijing Hosp, Beijing, Peoples R China
基金
瑞典研究理事会; 美国国家卫生研究院;
关键词
case-control study; family history; nasopharyngeal carcinoma (NPC); relative and cumulative risk; southern China; EPSTEIN-BARR-VIRUS; CANCER-RISK; POPULATION; AGGREGATION; SMOKING; SUSCEPTIBILITY; ASSOCIATION; INFECTION; RELATIVES; ALCOHOL;
D O I
10.1002/cncr.30643
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: To the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk in high-incidence populations. METHODS: The authors conducted a population-based case-control study of 2499 NPC cases and 2576 controls randomly selected in southern China from 2010 through 2014. Unconditional logistic regression was used to estimate multivariable-adjusted odds ratios (ORs) with 95% confidence intervals (95% CIs) associated with a family history of NPC. In addition, the authors compiled a reconstructed cohort comprising 40,781 first-degree relatives of cases and controls to calculate the lifetime cumulative risk of NPC. RESULTS: Individuals with a first-degree family history of NPC were found to be at a >4-fold risk of NPC (OR, 4.6; 95% CI, 3.5-6.1) compared with those without such a history, but had no excess risk of other malignancies. The excess risk was higher for a maternal than a paternal history and was slightly stronger for a sibling compared with a parental history, and for a sororal than a fraternal history. Among relatives of cases, the cumulative risk of NPC up to age 74 years was 3.7% (95% CI, 3.3%-4.2%), whereas that among relatives of controls was 0.9% (95% CI, 0.7%-1.2%). Cumulative risk was higher in siblings than in parents among relatives of cases, whereas no such difference was noted among relatives of controls. CONCLUSIONS: Individuals with a family history of NPC have a substantially higher risk of NPC. These relative and cumulative risk estimates can guide the development of strategies for early detection and clinical consultation in populations with a high incidence of NPC. (C) 2017 American Cancer Society.
引用
收藏
页码:2716 / 2725
页数:10
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