Neurophysiologic and neuropathological analysis of Parkinson's disease and its treatment with stereotaxic method

Complete stopping of tremor or its essential reduction have been achieved in 55 of 66 patients with Parkinson's disease. In 3 cases, there was a fatal outcome. The microstructural changes of nigrostriatal, thalamus and neocortex neurons are presented, and biopotentials led from these structures, along with clinical and neurophysiological effects of electrostimulation of thalamic and subthalamic regions, are evaluated. The results obtained in the study are used for explanation of tremor mechanism.