Maternal immune activation with high molecular weight poly(I:C) in Wistar rats leads to elevated immune cell chemoattractants

被引：5
|
作者：
Brown, Amelia M. [1 ]
Conn, Illya [1 ,2 ]
Boerrigter, Danny [1 ]
Weickert, Cynthia Shannon [1 ,3 ,4 ]
Purves-Tyson, Tertia D. [1 ,3 ]
机构：
[1] Neurosci Res Australia, Schizophrenia Res Lab, 139 Barker St,Margarete Ainsworth Bldg,Level 5, Sydney, NSW 2031, Australia
[2] Univ New South Wales, Fac Med, Sch Med Sci, Sydney, NSW 2052, Australia
[3] Univ New South Wales, Fac Med, Sch Psychiat, Sydney, NSW 2052, Australia
[4] Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2022年 / 364卷
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
Maternal immune activation (MIA); Wistar rat; Sickness behaviour; Cytokines; Sex differences; High molecular weight (HMW) poly(I; C); POLYINOSINIC-POLYCYTIDYLIC ACID; NEURODEVELOPMENTAL ANIMAL-MODEL; BLOOD-BRAIN-BARRIER; PREPULSE INHIBITION; PRENATAL INFECTION; DOPAMINERGIC HYPERFUNCTION; SPECTRUM DISORDERS; MICE LEADS; KAPPA-B; SCHIZOPHRENIA;
D O I：
10.1016/j.jneuroim.2022.577813
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Maternal immune activation (MIA) with poly(I:C) is a preclinical paradigm for schizophrenia and autism research. Methodological variations, including poly(I:C) molecular weight, contribute to inconsistencies in behavioural and molecular outcomes. We established in Wistar rats that 4 mg/kg high molecular weight (HMW)poly(I:C) on GD19 induces maternal sickness, smaller litters and maternal elevations of serum cytokines, including increases in monocyte chemoattractants. In adult offspring, we found that males have higher serum cytokines than females, and MIA did not alter peripheral cytokines in either sex. Our study will contribute to the effective use of the MIA model to elucidate the neurobiology of neurodevelopmental disorders.
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页数：14
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