Catalyst- and Oxidant-Free Electrochemical Halogenation Reactions of 2H-Indazoles with NaX (X=Cl, Br)

被引：12
|
作者：
Liu, Xin [1 ]
Wu, Zengzhi [1 ]
Feng, Chenglong [1 ]
Liu, Wenlu [1 ]
Li, Meichao [1 ]
Shen, Zhenlu [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 2022卷 / 17期
关键词：
Electrochemistry; Halogenation; 2H-indazoles; Synthetic methods; MEDICINAL CHEMISTRY; ELECTROSYNTHESIS; 3-HALOCHROMONES; CHLORINATION; BROMINATION; DERIVATIVES; INSIGHT; GREEN;
D O I：
10.1002/ejoc.202200262
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An environmentally friendly and highly efficient electrochemical method has been developed for halogenation of 2H-indazoles with cheap and commercially available NaX (X-Cl, Br) in the absence of metal catalysts and oxidants. Notably, this electrochemical process exhibits a broad substrate scope and high functional-group compatibility. A variety of 2H-indazoles are compatible with this transformation to give the corresponding products in modern to excellent yields. Also, this practical protocol avoids using external expensive supporting electrolytes. Last but not least, the procedure was carried out in an undivided cell at constant current condition under air atmosphere.
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页数：7
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