Differential expression of genes linked to the leukemia inhibitor factor signaling pathway during the estrus cycle and early pregnancy in the porcine endometrium

被引:8
|
作者
Kaczmarek, Monika M. [1 ,2 ]
Krawczynski, Kamil [1 ]
Najmula, Joanna [1 ]
Reliszko, Zaneta P. [1 ]
Sikora, Malgorzata [1 ]
Gajewski, Zdzislaw [2 ]
机构
[1] Polish Acad Sci, Inst Anim Reprod & Food Res, Mol Biol Lab, PL-10748 Olsztyn, Poland
[2] Univ Life Sci, Fac Vet Med, Dept Large Anim Dis, PL-02797 Warsaw, Poland
关键词
LIF; LIFR; IL6R; BCL2; TP53; Pig; FACTOR LIF; INTERLEUKIN-6;
D O I
10.1016/j.repbio.2014.06.003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The objective of this study was to determine the expression profiles of leukemia inhibitory factor (LIF) and its receptor (LIFR), interleukin 6 receptor (IL6R), tumor protein p53 (TP53) and B-cell CLL/lymphoma 2 (BCL2) in the porcine endometrium on selected days of the estrous cycle and pregnancy. Time- and reproductive status (estrous cycle/pregnancy)-specific patterns of expression were identified for all investigated genes. The most pronounced changes were seen on Days 12 and 14 of pregnancy when maternal recognition of pregnancy and implantation, respectively, occurs in pigs. (C) 2014 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
引用
收藏
页码:293 / 297
页数:5
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