Phosphinic acid-based inhibitors of tubulin polyglycylation

被引：2

作者：

Zhuang, Zaile ^{[1
]}

Cummings, Steven W. ^{[2
,3
]}

Roll-Mecak, Antonina ^{[2
,3
]}

Tanner, Martin E. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] NINDS, Cell Biol & Biophys Unit, Bethesda, MD 20892 USA

[3] NHLBI, Biochem & Biophys Ctr, Bethesda, MD 20892 USA

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 45期

基金：

加拿大自然科学与工程研究理事会; 美国国家卫生研究院;

关键词：

D-ALANINE LIGASE; BETA-TUBULIN; POSTTRANSLATIONAL MODIFICATION; GAMMA-GLUTAMATE; MESSENGER-RNAS; ADDING ENZYME; ALPHA-TUBULIN; TYROSINE; EXPRESSION; MECHANISM;

D O I：

10.1039/d2cc01783k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tubulin polyglycylation is a posttranslational modification that occurs primarily on the axonemes of flagella and cilia and has been shown to be essential for proper sperm motility. Inhibitors of both the initiase and elongase ligases (TTLL8 and TTLL10) are shown to inhibit tubulin glycylation in the low micromolar range.

引用

页码：6530 / 6533

页数：4

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