Monitoring laser treatment of port wine stains using phase-resolved optical Doppler tomography

被引：3
|
作者：
Zhao, YH [1 ]
Chen, ZP [1 ]
Saxer, CE [1 ]
de Boer, JF [1 ]
Majaron, B [1 ]
Verkruysse, W [1 ]
Nelson, JS [1 ]
机构：
[1] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92612 USA
来源：
COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICAL SCIENCE AND CLINICAL APPLICATIONS IV | 2000年 / 3915卷
关键词：
ODT; OCT; Hilbert transform; phase-resolved ODT; PWS; laser therapy;
D O I：
10.1117/12.384162
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We used a novel phase-resolved optical Doppler tomographic (ODT) technique, with very high flow velocity sensitivity (10 mu m/s) and high spatial resolution (10 mu m), to image blood flow in port wine stain (PWS) birthmarks in human skin. The variance of blood flow velocity is used to locate the PWS vessels in addition to the regular ODT images. Our device combines an ODT system and laser so that PWS blood flow can be monitored in situ before and after treatment. To our knowledge, this is the first clinical application of ODT to provide a fast semi-quantitative evaluation of the efficacy of PWS laser therapy in situ and in real-time.
引用
收藏
页码：237 / 242
页数：6
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