Variation in the C-Reactive Protein Gene Is Associated with Serum Levels of CRP in Patients with Acute Ischemic Stroke

被引：10
|
作者：
den Hertog, Heleen M. [1 ]
van den Herik, Evita G. [1 ]
Dippel, Diederik W. J. [1 ]
Koudstaal, Peter J. [1 ]
de Maat, Moniek P. M. [2 ]
机构：
[1] Erasmus MC Univ, Med Ctr, Dept Neurol, NL-3000 CA Rotterdam, Netherlands
[2] Erasmus MC Univ, Med Ctr, Dept Hematol, NL-3000 CA Rotterdam, Netherlands
来源：
CEREBROVASCULAR DISEASES | 2010年 / 29卷 / 04期
关键词：
CRP gene; CRP levels; Ischemic stroke; Acute phase; POLYMORPHISM; RISK;
D O I：
10.1159/000281835
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background and Purpose: Elevated levels of C-reactive protein (CRP) are found in up to three quarters of patients with acute ischemic stroke and are associated with poor outcome. We investigated whether haplotypes representing common variations in the CRP gene are associated with levels of CRP in patients with acute ischemic stroke. Methods: We included 185 patients with ischemic stroke in whom CRP was measured within 24 h of symptom onset. Common haplotypes within the CRP gene were determined by 3 genotype-tagging single-nucleotide polymorphisms (SNPs). Results: Four haplotypes with frequencies >5% covered 99.2% of the genetic variation. Haplotype 4 (CCG, frequency 8.3%) was associated with a 20.6 mg/l (95% CI, 9.8-30.4) stronger increase in CRP level as compared with haplotype 1 (CTC, frequency 33.7%). Conclusion: Variation in the CRP gene is associated with levels of CRP in acute ischemic stroke. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码：372 / 375
页数：4
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