t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia

被引：27
|
作者：
Vizmanos, JL
Larráyoz, MJ
Lahortiga, I
Floristán, F
Alvarez, C
Odero, MD
Novo, FJ
Calasanz, MJ
机构：
[1] Univ Navarra, Dept Genet, Sch Sci, E-31080 Pamplona, Spain
[2] Hosp Cruces, Hematol Serv, Serv Vasco Salud Osakidetza, Barcelona, Spain
来源：
GENES CHROMOSOMES & CANCER | 2003年 / 36卷 / 04期
关键词：
D O I：
10.1002/gcc.10174
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(I 0; 1 6)(q22;p 13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML. (C) 2003 Wiley-Liss, Inc.
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收藏
页码：402 / 405
页数：4
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