t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia

被引：27

作者：

Vizmanos, JL

Larráyoz, MJ

Lahortiga, I

Floristán, F

Alvarez, C

Odero, MD

Novo, FJ

Calasanz, MJ

机构：

[1] Univ Navarra, Dept Genet, Sch Sci, E-31080 Pamplona, Spain

[2] Hosp Cruces, Hematol Serv, Serv Vasco Salud Osakidetza, Barcelona, Spain

来源：

GENES CHROMOSOMES & CANCER | 2003年 / 36卷 / 04期

关键词：

D O I：

10.1002/gcc.10174

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF-CREBBP fusion in an 84-year-old patient diagnosed with AML M5b, in which the t(I 0; 1 6)(q22;p 13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML. (C) 2003 Wiley-Liss, Inc.

引用

页码：402 / 405

页数：4

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