Novel nucleosides via intramolecular functionalization of 2,2'-anhydrouridine derivatives

被引：23

作者：

McGee, DPC

Sebesta, DP

ORourke, SS

Martinez, RL

Jung, ME

Pieken, WA

机构：

[1] NEXSTAR PHARMACEUT INC,BOULDER,CO 80301

[2] UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90024

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 12期

关键词：

D O I：

10.1016/0040-4039(96)00227-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The generation of novel ribonucleoside analogues derived from 2,2'-anhydrouridines by a 3'-hydroxyl directed intramolecular nucleophilic substitution of the 2'-position is described. The methodology allows for the efficient, regio- and stereoselective elaboration of the 2'-position, often under exceptionally mild reaction conditions.

引用

页码：1995 / 1998

页数：4

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