Novel nucleosides via intramolecular functionalization of 2,2'-anhydrouridine derivatives

被引：23
|
作者：
McGee, DPC
Sebesta, DP
ORourke, SS
Martinez, RL
Jung, ME
Pieken, WA
机构：
[1] NEXSTAR PHARMACEUT INC,BOULDER,CO 80301
[2] UNIV CALIF LOS ANGELES,DEPT CHEM & BIOCHEM,LOS ANGELES,CA 90024
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 12期
关键词：
D O I：
10.1016/0040-4039(96)00227-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The generation of novel ribonucleoside analogues derived from 2,2'-anhydrouridines by a 3'-hydroxyl directed intramolecular nucleophilic substitution of the 2'-position is described. The methodology allows for the efficient, regio- and stereoselective elaboration of the 2'-position, often under exceptionally mild reaction conditions.
引用
收藏
页码：1995 / 1998
页数：4
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