Facile syntheses of N-(1-alkenyl) derivatives of 2,4-pyrimidinediones

被引：7
|
作者：
Henriksen, U [1 ]
机构：
[1] Univ Copenhagen, HC Orsted Inst, Dept Chem, DK-2100 Copenhagen, Denmark
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2000年 / 19卷 / 07期
关键词：
D O I：
10.1080/15257770008035032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
N-(1-alkenyl) derivatives of 2,4-Pyrimidinediones (6 - 9) were prepared in a one pot synthesis from aldehydes and the nucleobases using trimethylsilyl trifluoromethanesulfonate (TfOTMS) as coupling reagent. Presilylation of the above nucleobases, and N-6-benzoyladenine, with excess N,O-bis(trimethylsilyl)acetamide (BSA) followed by addition of one mol eq. TfOTMS yielded the N-(1-trimethylsilyloxyalkyl) derivatives 1 - 5.
引用
收藏
页码：1093 / 1100
页数：8
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