Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus

被引：20
|
作者：
Kellner, Erinn S. [1 ,2 ]
Lee, Pui Y. [1 ,2 ,3 ]
Li, Yi [1 ,2 ]
Switanek, Juliana [1 ,2 ]
Zhuang, Haoyang [1 ,2 ]
Segal, Mark S. [1 ,2 ,3 ]
Sobel, Eric S. [1 ,2 ,4 ]
Satoh, Minoru [1 ,2 ,4 ]
Reeves, Westley H. [1 ,2 ,4 ]
机构：
[1] Univ Florida, Div Rheumatol & Clin Immunol, Gainesville, FL 32610 USA
[2] Univ Florida, Ctr Autoimmune Dis, Gainesville, FL 32610 USA
[3] Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA
[4] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 223卷 / 1-2期
关键词：
Systemic lupus erythematosus; Depression; Fatigue; Type-I interferon; INDUCIBLE GENE-EXPRESSION; CHRONIC HEPATITIS-C; DISEASE-ACTIVITY; PSYCHIATRIC MANIFESTATIONS; COGNITIVE DYSFUNCTION; IFN-ALPHA; ANTIBODIES; SLE; ACTIVATION; RECEPTORS;
D O I：
10.1016/j.jneuroim.2010.03.018
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Patients with systemic lupus erythematosus (SLE) often suffer from depression and fatigue in addition to the physical manifestations of the autoimmune disease. Elevated production of type-I interferons (IFN-I) has been found in lupus patients and IFN-I can precipitate a variety of neuropsychiatric side effects. This study was conducted to evaluate the relationship between dysregulated IFN-I production and the presence of depression or fatigue in lupus patients. Through cross-sectional and longitudinal analysis we found no significant correlation between abnormal IFN-I levels (as measured by peripheral blood expression of IFN-I-stimulated genes) and neuropsychiatric manifestations. Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE.
引用
收藏
页码：13 / 19
页数：7
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