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Cortical spreading depression induces an LTP-like effect in rat neocortex in vitro

被引：56
|
作者：
Footitt, DR
Newberry, NR
机构：
[1] Univ Oxford, Radcliffe Infirm, Dept Clin Pharmacol, Oxford OX2 6HE, England
[2] Univ Oxford, Radcliffe Infirm, SmithKline Beecham Ctr Appl Neuropsychobiol, Oxford OX2 6HE, England
来源：
BRAIN RESEARCH | 1998年 / 781卷 / 1-2期
关键词：
cortical-spreading depression; long-term potentiation; NMDA; AMPA;
D O I：
10.1016/S0006-8993(97)01359-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have developed an in vitro model of spreading depression (SD) in rat neocortex. KCI application induced a propagating wave of SD associated with a change of optical lucency and an extracellular negative wave. Both of these were abolished by aminophosphonovaleric acid (100 mu M), indicating SD's mediation by NMDA receptors. SD abolished synaptically-mediated field potentials in layer II and this depression was followed by a previously undescribed, sustained LTP-Like enhancement of transmission. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：339 / 342
页数：4
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