Influential factors of epilepsy following aneurismal subarachnoid hemorrhage

Objective: To explore the risk factors for epilepsy following aneurismal subarachnoid hemorrhage (ASH). Methods: Clinical data of patients with ASH who underwent microsurgical clipping in our hospital between January 2006 and July 2014 were retrospectively analyzed. Clinical data included age, a history of hypertension, duration of consciousness disorder (>= one hour, < one hour), score of Glasgow Coma Scale (GCS) and Fisher grade on admission, ruptured aneurysms, complications (rebleeding, cerebral vasospasm and hydrocephalus), surgical timing and score of Glasgow Outcome Scale (GOS). The secondary epilepsy was divided into early epilepsy (< 24 h) and late epilepsy (> 24 h), and then the influential factors of epilepsy occurring in different periods were respectively analyzed. Results: Of 177 patients with ASH, 14 had early epilepsy, 16 had late epilepsy and 3 had both early and late epilepsy. The patients with a history of hypertension readily had early epilepsy (P < 0.05), and the patients with GCS of 8-14 or hydrocephalus readily had late epilepsy (P < 0.05). Conclusion: Hypertension is a risk factor of early epilepsy, and GCS of 8-14 or hydrocephalus are risk factors of late epilepsy. This study provides a basis for early diagnosis, prevention and treatment of epilepsy.